Novel Pneumococcal Serotypes 6C and 6D: Anomaly or Harbinger
نویسندگان
چکیده
منابع مشابه
Novel pneumococcal serotypes 6C and 6D: anomaly or harbinger.
Clinical use of the 7-valent pneumococcal protein conjugate (PCV7) vaccine, which includes serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F, dramatically reduced invasive pneumococcal disease (IPD); however, the effectiveness was diminished due to serotype shift. Although shift due to known serotypes was anticipated, shift by misidentified serotypes was unexpected. We describe the experience with new...
متن کاملDifferential effects of pneumococcal vaccines against serotypes 6A and 6C.
BACKGROUND Because classic pneumococcal serotyping methods cannot distinguish between serotypes 6A and 6C, the effects of pneumococcal vaccines against serotype 6C are unknown. Pneumococcal vaccines contain serotype 6B but not serotypes 6A and 6C. METHODS We used a phagocytic killing assay to estimate the immunogenicity of the 7-valent conjugate vaccine (PCV7) in children and the 23-valent po...
متن کاملSerotype 6B from a pneumococcal polysaccharide vaccine induces cross-functional antibody responses in adults to serotypes 6A, 6C, and 6D
Cross-reactivity of pneumococcal capsular polysaccharides is a key element for formulating pneumococcal vaccines and evaluating vaccine efficacy. This study examined whether 23-valent pneumococcal polysaccharide vaccine (PPSV23), which only contains 6B, can elicit cross-functional immune responses against recently discovered serotypes (6C and 6D), as well as against 6A, in 2 adult age groups.Yo...
متن کاملFrequency and molecular characterization of invasive isolates of Streptococcus pneumoniae serotypes 6C and 6D in Colombia.
INTRODUCTION Serogroup 6 of Streptococcus pneumoniae initially consisted of the 6A and 6B serotypes, but in recent years, the 6C and 6D serotypes were reported. The aim of this study was to determine the frequency and molecular characterization of invasive S. pneumoniae isolates serotypes 6C and 6D in Colombia, from 1994 to 2013. METHODOLOGY All the isolates recovered during the surveillance ...
متن کاملStreptococcus pneumoniae serotype 6D cross-reacting with serotype 6A, 6B, and 6C factor sera.
We read the papers of Bratcher and Nahm (3) and Oftadeh et al. (8) with interest. Both papers reported that Streptococcus pneumoniae serotype 6D isolates react with factor antiserum specific to serotype 6C in addition to that to 6B. Pneumococcal serotype 6C, first reported in 2007, cross-reacts serologically with serotype 6A but is differentiated by a change in the wciN gene (wciN ) among the c...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2012
ISSN: 1058-4838,1537-6591
DOI: 10.1093/cid/cis691